Table 2. Overview available samples and measurements

 Subject Oral rinse, Blood, Salvia, Tumour tissue
 Patient-reported outcome measures
 Subject  Instrument
Measured once:
NQ_x101 Demographics Age and gender
NQ_x103 Education and literacy Education and literacy
NQ_x104 Country of birth and family Country of birth and family
NQ_x112 Personality (big five) NEO Five Factor Inventory (NEO-FFI)
NQ_x113 Locus of control Pearlin Schooler and Mastery Scale (PSMS)
NQ_x115 Coping Utrecht Coping List (UCL)
NQ_x116 Social Desirability Social desirability questionnaire (study-specific questionnaire)
NQ_x127 Fertility Study-specific questionnaire (women only)
Measured every time point:
Questionnaire A
NQ_x102 Weight Gender, age, self-reported weight
NQ_x106 Smoking and nicotine dependence Smoking habits (study-specific questionnaire)
NQ_x107 Alcohol intake and dependence Alcohol (study-specific questionnaire)
NQ_x108 Drugs use Drugs (study-specific questionnaire)
NQ_x109 Generic quality of life EuroQol (EQ-5D + VAS)
NQ_x110 Disease-specific quality of life EORTC QLQ-C30
NQ_x111 Tumour-specific quality of life EORTC QLQ-H&N35
NQ_x114 Coping Mental Adjustment to Cancer (MAC)
NQ_x117 Severity anxiety/depression Hospital Anxiety and Depression Scale (HADS)
NQ_x118 Fatigue Multidimensional Fatigue Inventory (MFI)
NQ_x119 Swallowing Swallowing Quality of Life Questionnaire (SwalQoL)
NQ_x120 Speech Speech Handicap Index (SHI)
NQ_x121 Xerostomia Groningen Radiation Induced Xerostomia (GRIX)
NQ_x122 Shoulder problems Shoulder Disability Questionnaire (SDQ)
NQ_x123 Fear of recurrence Cancer Worry Scale (CWS)
NQ_x128 Social support Social Support List – Interactions (SSL-I12)
NQ_x130 Physical activity Physical Activity Scale for the Elderly (PASE)
Questionnaire B
NQ_x202 Participation Impact on Participation and Autonomy (IPA)
NQ_x203 Self-perceived neurocognitive function Cognitive Failures Questionnaire (CFQ)
NQ_x204 Self-efficacy Generalized Self-Efficacy Scale (GSE)
NQ_x205 Sleep quality Pittsburgh Sleep Quality Index (PSQI)
NQ_x206 Life events Brugha/List of Threatening Experiences
NQ_x207 Post-traumatic stress Impact of Event Scale-Revised (IES-R)
NQ_x208 Loneliness Loneliness Scale (deJong Gierveld)
NQ_x209 Hearing Caron
NQ_x210 Sexual functioning – men International Index of Erectile Function (IIEF)
NQ_x211 Sexual functioning – women  Female Sexual Function Index (FSFI)
NQ_x212 Supportive care needs Supportive Care Needs Survey Short-Form 34 (SCNS-SF34) and  SCNS head and neck cancer module (SCNS-HNC)
NQ_x214 Leisure activities  Study-specific questionnaire
 Home based interview and test
Subject  Instrument
Measured during home-based visit:
NQ_x302  Anxiety disorders WHO–Composite International Diagnostic Interview (CIDI)
NQ_x303  Major Depressive Disorder (MDD)  WHO–Composite International Diagnostic Interview (CIDI)
NQ_x304 Verbal learning and verbal recall: immediate recall  Hopkins Verbal Learning Test (HVLT)
NQ_x305 Visual motor scanning speed  Trailmaking A
NQ_x306 Executive functioning  Trailmaking B
NQ_x307 Verbal fluency  Controlled Oral Word Association Test (COWA)
NQ_x308 Daily life  Instrumental Activities Daily Life (IADL)
NQ_x309 Pain  Brief Pain Inventory (BPI)
  NQ_x310 Verbal learning and verbal recall: Delayed  Hopkins Verbal Learning Test (HVLT) – Delayed Recall
NQ_x311 Blood pressure  Systolic and diastolic blood pressure
NQ_x312 Body composition  Weight, height, BMI, circumferences (waist and hip), skinfolds (4 measurements)
NQ_x313 Pulmonary function  Peak flow
NQ_x314 Muscle strength  JAMAR handgrip dynamometer, 30s chair stand test
NQ_x315 Nutrition status  Mini Nutritional Assessment (MNA)
NQ_x317 Oral and shoulder function  Functional Rehabilitation Outcome Grades (FROG)
NQ_x318 Cardiorespiratory fitness  Chester Step test
NQ_001 Dietary intake  Recall dietary intake
NQ_003 Heart rate  Polar
Measured after home-based visit:
NQ_002 Objectively measured physical activity  Accelerometer (gt3x en agd)
 Clinical data
NQ_x401 Baseline eCRF
NQ_x402 Follow-up eCRF (2 years follow-up)